Dr Christopher Staples

Uwch Ddarlithydd mewn Gwyddorau Biofeddygol (Bioleg Canser)

c.staples@bangor.ac.uk

  • PhD: Regulation of MAP kinase phosphatases
    University of Dundee, 2006鈥�2010

Teaching Credits

MSE-3016 Pathophysiology (10 credits) - Module Organiser

MSE-2025 Molecular Biology and Biochemistry (10 credits)聽

MSE-3013 Third Year Research Project聽

MSE-4025 Dissertation

Teaching and Supervision Roles

Undergraduate project/dissertation supervision. Supervision of PhD, MSc and MRes students.

Other roles

College representative on Research Concordat Committee

External and internal viva voce examiner

Teaching and Scholarship Awards

PGCertHE Stage 1 (2017)

PGCertHE Stage 2 (2018)

Fellow of the Higher Education Academy (HEA)

Work in the Staples laboratory focuses largely on the characterisation of novel genome stability factors. Genome instability and DNA damage are central pathogenic mechanisms involved in cancer predisposition, premature ageing and neurodegeneration. Indeed, some cancer therapies target cancer-specific defects in DNA repair or replication fork protection mechanisms, and as such a complete understanding of such mechanisms is a major asset in the fight against cancer.

We have identified several novel DNA repair and replication fork protection factors, and our aim is to gain mechanistic insight into the function of these largely unstudied proteins with the ultimate goal of using this knowledge to design novel cancer therapies and/or predict therapeutic response.

Investigation of novel replication fork protection factors Investigation of small-molecule inhibitors of the DNA damage response

2023

  • Cyhoeddwyd
    Crozier, L., Foy, R., adib, R., Kar, A., Holt, J., Pareri, A., Valverde, J., Riviera, R., Weston, W., Wilson, R., Regnault, C., Whitfield, P., Badonyi, M., Bennett, L., Vernon, E., Gamble, A., Marsh, J., Staples, C., Saurin, A., Barr, A. & Ly, T., 16 Tach 2023, Yn: Molecular Cell. 83, 22, t. 4062-4077 15 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Elgar, C. E., Yusoh, N. A., Tiley, P. R., Kolozsv谩ri, N., Bennett, L., Gamble, A., P茅an, E. V., Davies, M. L., Staples, C., Ahmad, H. & Gill, M. R., 18 Ion 2023, Yn: Journal of the American Chemical Society. 145, 2, t. 1236-1246 11 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid

2020

  • Cyhoeddwyd
    Bennett, L., Wilkie, A., Antonopoulou, E., Ceppi, I., Sanchez, A., Vernon, E., Gamble, A., Myers, K. N., Collis, S. J., Cejka, P. & Staples, C., 10 Gorff 2020, Yn: Science Advances. 6, 28, 10 t., eaba5974.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid

2017

  • Cyhoeddwyd
    Williams, D. T. & Staples, C., 25 Awst 2017, Personalised Medicine. El-Khamisy, S. (gol.). Springer, Cyfrol 1007. t. 1-16 16 t. (Advances in Experimental Medicine and Biology).
    Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd 鈥� Pennod

2016

  • Cyhoeddwyd
    Barone, G., Staples, C. J., Ganesh, A., Patterson, K. W., Bryne, D. P., Myers, K. N., Patil, A. A., Eyers, C. E., Maslen, S., Skehel, J. M., Eyers, P. A. & Collis, S. J., 14 Hyd 2016, Yn: Nucleic Acids Research. 44, 18, t. 8772-8785 14 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Staples, C. J., Barone, G., Myers, K. N., Ganesh, A., Gibbs-Seymour, I., Patil, A. A., Beveridge, R. D., Daye, C., Beniston, R., Maslen, S., Ahel, I., Skehel, J. M. & Collis, S. J., 6 Medi 2016, Yn: Cell. 16, 10, t. 2565-75 11 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Myers, K. N., Barone, G., Ganesh, A., Staples, C. J., Howard, A. E., Beveridge, R. D., Maslen, S., Skehel, J. M. & Collis, S. J., 14 Hyd 2016, Yn: Scientific Reports. 6, t. 35548
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid

2014

  • Cyhoeddwyd
    Staples, C. J., Myers, K. N., Beveridge, R. D., Patil, A. A., Howard, A. E., Barone, G., Lee, A. J., Swanton, C., Howell, M., Maslen, S., Skehel, J. M., Boutlon, S. J. & Collis, S. J., 1 Gorff 2014, Yn: Journal of Cell Science. 127, t. 2910-2919
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Beveridge, R. D., Staples, C. J., Patil, A. A., Myers, K. N., Maslen, S., Skehel, J. M., Boulton, S. J. & Collis, S. J., 29 Hyd 2014, Yn: Cell Cycle. 13, 21, t. 3450-3459
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid

2011

  • Cyhoeddwyd
    Dickinson, R. J., Delavaine, L., Cejudo-Mar铆n, R., Stewart, G., Staples, C. J., Didmon, M. P., Trinidad, A. G., Alonso, A., Pulido, R. & Keyse, S. M., 4 Tach 2011, Yn: Journal of Biological Chemistry. 286, 44, t. 38018-26 9 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid

2010

  • Cyhoeddwyd
    Staples, C. J., Owens, D. M., Maier, J. V., Cato, A. C. B. & Keyse, S. M., 20 Awst 2010, Yn: Journal of Biological Chemistry. 285, 34, t. 25928-40 13 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid

2009

  • Cyhoeddwyd
    Kucharska, A., Rushworth, L. K., Staples, C., Morrice, N. A. & Keyse, S. M., Rhag 2009, Yn: Cellular Signalling. 21, 12, t. 1794-805 12 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid

2008

  • Cyhoeddwyd
    Ekerot, M., Stavridis, M. P., Delavaine, L., Mitchell, M. P., Staples, C., Owens, D. M., Keenan, I. D., Dickinson, R. J., Storey, K. G. & Keyse, S. M., 1 Meh 2008, Yn: Biochemical Journal. 412, 2, t. 287-98 12 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid

2007

  • Cyhoeddwyd
    Graham, D. A., Staples, C., Wilson, C. J., Jewhurst, H., Cherry, K., Gordon, A. & Rowley, H. M., Medi 2007, Yn: Journal of Fish Biology. 30, 9, t. 533-43 11 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn 鈥� Erthygl 鈥� adolygiad gan gymheiriaid

2022

  • There is an urgent requirement to identify specific, precision medicine drug targets that selectively kill PDACs with mutations in BRCA2 and other DNA repair factors, or which sensitise them further to existing treatments. We are therefore applying for funding to develop CRISPR-Cas9 dropout screening at 香港六合彩挂牌资料 鈥揳 powerful technique for identifying novel precision medicine drug targets in cancer cells. While our initial focus is on PDAC, once in place this methodology can be applied to drive the discovery of drug targets for a wide array of human diseases.

    Funding awarded through the 香港六合彩挂牌资料 Innovation and Impact Award (Research Wales Innovation Funding). Value = 拢49,466

    1 Ebr 2022 鈥� 31 Maw 2023

    Gweithgaredd: Arall (Cyfrannwr)

2021

  • 20 Meh 2021

    Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)

  • Invited talk at the 26th UK Cilia Network Symposium

    17 Mai 2021

    Gweithgaredd: Cyflwyniad llafar (Siaradwr)

  • Member of scientific panel

    9 Mai 2021 鈫�

    Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)

  • 9 Mai 2021

    Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)

2020

  • Peer reviewer

    7 Tach 2020

    Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)

  • Peer-reviewer for UKRI Future Leaders Fellowships

    25 Hyd 2020

    Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)

  • Peer review

    11 Medi 2020

    Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)

  • Reviewed a BBSRC Responsive Mode Application

    31 Awst 2020

    Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)

  • 21 Ebr 2020

    Gweithgaredd: Arholiad (Arholwr)

  • 2 Ebr 2020

    Gweithgaredd: Arholiad (Arholwr)

  • Provided peer review for a BBSRC project grant application

    4 Maw 2020

    Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)

  • Acted as peer reviewer

    7 Ion 2020

    Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)

2019

  • Supervised by Nikki Copeland

    13 Meh 2019

    Gweithgaredd: Arholiad (Arholwr)

  • External examiner

    4 Meh 2019

    Gweithgaredd: Arholiad (Arholwr)

  • 15 min talk at international conference

    2019

    Gweithgaredd: Cyflwyniad llafar (Siaradwr)

2018

  • Invited speaker to research seminar series

    18 Maw 2018

    Gweithgaredd: Cyflwyniad llafar (Siaradwr)

  • 29 Ion 2018

    Gweithgaredd: Arholiad (Arholwr)

2017

  • 9 Tach 2017

    Gweithgaredd: Arholiad (Arholwr)

  • Invited speaker to research seminar series

    11 Mai 2017

    Gweithgaredd: Cyflwyniad llafar (Siaradwr)

  • 01/07/2024 鈥� 15/07/2027 (Wrthi'n gweithredu)

  • 03/06/2024 鈥� 30/06/2026 (Wrthi'n gweithredu)

  • 01/01/2024 鈥� 15/01/2026 (Wrthi'n gweithredu)

  • 01/12/2023 鈥� 15/12/2026 (Wrthi'n gweithredu)

  • 01/10/2023 鈥� 30/11/2026 (Wrthi'n gweithredu)

  • 01/04/2023 鈥� 15/04/2025 (Wrthi'n gweithredu)

  • 01/10/2022 鈥� 31/12/2025 (Wrthi'n gweithredu)

  • 01/10/2022 鈥� 31/03/2024 (Wedi gorffen)

  • 01/07/2022 鈥� 31/03/2024 (Wedi gorffen)

  • 01/05/2021 鈥� 31/08/2021 (Wedi gorffen)

  • 01/01/2021 鈥� 31/03/2024 (Wedi gorffen)

  • 01/02/2020 鈥� 29/02/2024 (Wedi gorffen)

  • 01/12/2019 鈥� 31/12/2023 (Wedi gorffen)

  • 01/07/2019 鈥� 01/08/2022 (Wedi gorffen)

  • 01/06/2019 鈥� 01/08/2019 (Wedi gorffen)

  • 01/01/2019 鈥� 30/06/2022 (Wedi gorffen)

  • 01/05/2018 鈥� 31/07/2023 (Wedi gorffen)

  • 01/11/2016 鈥� 31/08/2020 (Wedi gorffen)

  • 01/10/2016 鈥� 31/07/2018 (Wedi gorffen)

  • 01/10/2016 鈥� 19/08/2023 (Wedi gorffen)